the biggest thing i’ve found for me is stress level, when stress is high, i do things that lead to weight gain, when low, i do things that lead to weight loss (or at least hovering somewhere close to my “ideal” weight).
having noted the underlying disease, the best thing i’ve found to treat the symptom is exercise, preferably something that combines weights and vigorous, aerobic activity. and, if at all possible, choose an activity that has a purpose other than just as exercise, but sometimes that’s a little difficult (it’s unlikely that I’m going to be carrying a deer thru 30 miles of woods 3+ times a week anytime in the near future, for example).
if you really want something specific that will lead to some weight loss, then try this daily for at least 6-8 months:
first, choose an aerobic activity that works for you, whether that be walking (in place or not), biking (again, in place or not), jumping jacks, Tae Bo, whatever.
1 set of 10 reps of leg curls (whatever weight works for you)
do 5 minutes of your chosen aerobic activity
do a 2nd set of 10 reps of leg curls
do 5 minutes of your chosen aerobic activity
do a 3rd set of leg curls
another 5 minutes of your chosen aerobic activity
rinse and repeat, but substitute bench presses, lats, crunches, and bicep curls for subsequent iterations.
granted, you could sub out weight exercises as desired, but my suggestion is to try to hit for several different muscle groups.